There's always a tradeoff, but t's better to spend a few more minutes on deco rather than push the CNS limits. The deco time difference between 18/45 and 21/35 is negligable anyway.
Many of us gave up 21/35 for 18/45 years ago just to cut down on the number of deicated cylinders we have ready to go and simplify the logistics of weekend travel planning.
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:-)